Can Ketones Give You a Metabolic Edge?
Hey everyone! Let’s dive into something really intriguing that Dr. Benjamin Bikman talked about at the Low Carb Denver 2019 conference. He explored whether ketones can give us a metabolic advantage. He explained how mitochondria—the “energy factories” in our cells—can use nutrient energy in two different ways: one is super efficient, and the other is a bit “wasteful.” But here’s the twist: that “wasteful” way might actually help with weight loss.
The Role of Mitochondria
So, mitochondria need oxygen to burn nutrients and produce energy. In the process, they generate a bit of heat. But mitochondria are smarter than a regular campfire. They don’t just produce heat; they also create a molecule called ATP, which is like the “energy currency” our cells use to get stuff done. Think of it this way: ATP powers your muscles when they contract and relax.
The Relationship Between Insulin and Ketones
Dr. Bikman also talked about what happens when fat breakdown is high for a long time. The body starts producing these little molecules called ketones. When you’re in ketosis—meaning your body is actively making ketones—almost half of the fat you burn goes into making these ketones. This only happens when insulin levels are low. Insulin and ketones are like two sides of a seesaw: when insulin is low, fat burning increases, and so does ketone production.
The Science Behind It
When insulin levels are low, a molecule called Acetyl-CoA builds up. Acetyl-CoA is a key player in biochemistry and can go down different metabolic pathways. Because insulin is low, it can’t be used to make fat. Instead, it gets diverted into making ketones. This process depends on well-functioning mitochondria, and it can even promote the creation of new mitochondria. Ketones also protect mitochondria from damage by reducing the formation of reactive oxygen species (ROS) and boosting antioxidants like glutathione.
The Benefits of Ketones
Ketones are not just a byproduct of fat burning; they also have protective effects on the brain. As a high-energy fuel, they provide more energy to brain cells, which is inherently neuroprotective. Additionally, ketones can reduce neuroinflammation and oxidative stress through various mechanisms, which is great for brain health.
Dr. Bikman’s talk really opened my eyes to how ketones and mitochondria work together. Whether you’re new to keto or already a pro, understanding this relationship can help you optimize your diet and maybe even shed some extra pounds.
If you want to learn more, check out the full presentation from the Low Carb Denver conference. The video is available with captions and a transcript, and you can access it with a free trial or membership.
Thanks for reading, and stay curious!
